منابع مشابه
Redox regulation of Janus kinase
The redox regulation of Janus kinases (JAKs) is a complex subject. Due to other redox-sensitive kinases in the kinome, redox-sensitive phosphatases, and cellular antioxidant systems and reactive oxygen species (ROS) production systems, the net biological outcomes of oxidative stress on JAK-dependent signal transduction vary according to the specific biological system examined. This review begin...
متن کاملNitric oxide and thiol redox regulation of Janus kinase activity.
The activation of Janus kinases (JAKs) is crucial for propagation of the proliferative response initiated by many cytokines. The proliferation of various cell lines, particularly those of hematopoietic origin, is also modulated by mediators of oxidative stress such as nitric oxide and thiol redox reagents. Herein we demonstrate that nitric oxide and other thiol oxidants can inhibit the autokina...
متن کاملRedox regulation of protein kinase G
Oxidants were once primarily considered in biology and medicine in terms of the injury they might cause. However, oxidants are now known to play crucial roles in homeostatic control of cells and tissues during health. Oxidative modification of proteins with a coupled alteration in function allows cells to sense and transduce these 'oxidant signals' into a biological response. We looked for prot...
متن کاملRedox Regulation of the AMP-Activated Protein Kinase
UNLABELLED Redox state is a critical determinant of cell function, and any major imbalances can cause severe damage or death. OBJECTIVES The aim of this study is to determine if AMP-activated protein kinase (AMPK), a cellular energy sensor, is activated by oxidants generated by Berberine in endothelial cells (EC). METHODS Bovine aortic endothelial cells (BAEC) were exposed to Berberine. AMP...
متن کاملRedox Regulation of Pka Signaling: Kinase versus Phosphatase Inactivation
Many components of cellular signaling pathways are sensitive to regulation by oxidation and reduction. Previously, we described the inactivation of cAMP dependent protein kinase (PKA) by direct oxidation of a reactive cysteine in the activation loop of the kinase. In the present study, we demonstrate that in Hela cells PKA activity follows a biphasic response to thiol oxidation. Under mild oxid...
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ژورنال
عنوان ژورنال: JAK-STAT
سال: 2013
ISSN: 2162-3996
DOI: 10.4161/jkst.26141